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According to the World Tourism Organization, the number of international tourist arrivals in 2004 reached an alltime record of 763 million. This number represents an increase over the 2003 figure of almost 11%—the highest and the only double-digit percentage increase since 1980, when these statistics were first collected. Not only are more people traveling; travelers are seeking more exotic and remote destinations. Studies show that 50–75% of short-term travelers to the tropics or subtropics report some health impairment. Most of these health problems are minor: only 5% require medical attention, and <1% require hospitalization. Although infectious agents contribute substantially to morbidity among travelers, these pathogens account for only ∼1% of deaths in this population. Cardiovascular disease and injuries are the most frequent causes of death among travelers from the United States, accounting for 49% and 22% of deaths, respectively. Age-specific rates of death due to cardiovascular disease are similar among travelers and nontravelers. In contrast, rates of death due to injury (the majority from motor vehicle, drowning, or aircraft accidents) are several times higher among travelers. Figure 4-1 summarizes the monthly incidence of health problems during travel in developing countries.


GENERAL ADVICE

Health maintenance recommendations are based not only on the traveler’s destination but also on assessment of risk, which is determined by health status, specific itinerary, and lifestyle during travel. Detailed information regarding country-specific risks and recommendations may be obtained from the Centers for Disease Control and Prevention (CDC) publication Health Information for International Travel (available at www.cdc.gov/travel/yb/). Fitness for travel is an issue of growing concern in view of the increased numbers of elderly and chronically ill individuals journeying to exotic destinations (see “Travel and Special Hosts” later in the chapter). Since most commercial aircrafts are pressurized to 2500 m (8000 ft) above sea level (corresponding to a PaO2 of ∼55 mmHg), individuals with serious cardiopulmonary problems or anemia should be evaluated before travel. In addition, those who have recently had surgery, a myocardial infarction, a cerebrovascular accident, or a deep-vein thrombosis may be at high risk for adverse events during flight.A summary of current recommendations regarding fitness to fly has been published by the Aerospace Medical Association Air Transport Medicine Committee (www. asma. org/publications/). A pretravel health assessment may be advisable for individuals considering particularly adventurous recreational activities, such as mountain climbing and scuba diving.


IMMUNIZATIONS FOR TRAVEL

Immunizations for travel fall into three broad categories: routine (childhood/adult boosters that are necessary regardless of travel), required (immunizations that are mandated by international regulations for entry into certain areas or for border crossings), and recommended (immunizations that are desirable because of travel-related risks).Vaccines commonly given to travelers are listed in Table 4-1. Routine Immunizations Diphtheria, Tetanus, and Polio Diphtheria (Chap. 38) continues to be a problem worldwide. Large outbreaks have occurred over the past decade in the independent states formerly encompassed by the Soviet Union. Serologic surveys show that tetanus (Chap. 40) antitoxin is lacking in many North Americans, especially in women over the age of 50.The risk of polio (Chap. 94) to the international traveler is extremely low, and wild-type poliovirus has been eradicated from the Western Hemisphere and Europe. However, studies in the United States suggest that 12% of adult travelers are unprotected against at least one poliovirus serogroup. Foreign travel offers an ideal opportunity to have these immunizations updated.With the recent increase in pertussis in adults, the diphtheria-tetanus-acellular pertussis (Tdap) combination may replace the Td vaccine as a 10-year booster once an adult polio immunization has been administered. Measles Measles (rubeola) continues to be a major cause of morbidity and mortality in the developing world (Chap. 95). Several outbreaks of measles in the United States have been linked to imported cases.


The group at highest risk consists of persons born after 1956 and vaccinated before 1980, in many of whom primary vaccination failed. Influenza Influenza—possibly the most common vaccine-preventable infection in travelers—occurs year-round in the tropics and during the summer months in the Southern Hemisphere (coinciding with the winter months in the Northern Hemisphere). One prospective study showed that influenza developed in 1% of travelers to Southeast Asia per month of stay.Vaccination should be considered for all travelers to these regions, particularly those who are elderly or chronically ill. Travel-related influenza continues to occur during summer months in Alaska and the Northwest Territories of Canada among cruiseship passengers and staff (Chap. 88). Pneumococcal Infection Regardless of travel, pneumococcal vaccine should be administered routinely to the elderly and to persons at high risk of serious infection, including those with chronic heart, lung, or renal disease and those who have been splenectomized or have sickle cell disease (Chap. 34). Required Immunizations Yellow Fever Documentation of vaccination against yellow fever (Chap. 99) may be required as a condition of entry into or passage through countries of Sub-Saharan Africa and equatorial South America, where the disease is endemic or epidemic, or for entry into countries at risk of having the infection introduced.


This vaccine is given only by state-authorized yellow fever centers, and its admin- 45 istration must be documented on an official International Certificate of Vaccination. A registry of U.S. clinics that provide the vaccine is available from the CDC (www. cdc.gov/travel/). Recent data suggest that fewer than 50% of travelers entering areas endemic for yellow fever are immunized. Severe adverse events associated with this vaccine have recently increased in incidence. First-time vaccine recipients may present with a syndrome characterized as either neurotropic (1 case per 150,000–250,000 doses) or viscerotropic (1 case per 200,000–300,000 doses; among persons >60 years of age, 1 case per 40,000–50,000).Advanced age and thymic disease seem to increase the risk for these adverse events (www.cdc.gov/nip/publications/VIS/vis-yf.pdf ). Meningococcal Meningitis Protection against meningitis (using one of the quadrivalent vaccines) is required for entry into Saudi Arabia during the Hajj (Chap. 44). Recommended Immunizations Hepatitis A and B Hepatitis A (Chap. 92) is one of the most frequent vaccine-preventable infections of travelers. The risk is six times greater for travelers who stray from the usual tourist routes.


The mortality rate for hepatitis A increases with age, reaching almost 3% among individuals over age 50. Of the four hepatitis A vaccines currently available in North America (two in the United States), all are interchangeable and have an efficacy rate of >95%. Long-stay overseas workers appear to be at considerable risk for hepatitis B infection (Chap. 92). The recommendation that all travelers be immunized against hepatitis B before departure is supported by two recent studies showing that 17% of the assessed travelers who received health care abroad had some type of injection; according to the World Health Organization, nonsterile equipment is used for up to 75% of all injections given in the developing world. A combined hepatitis A and B vaccine is now available in the United States and has been approved for administration on a 3-week accelerated schedule. It seems prudent to consider immunization of all travelers against hepatitis A and B. Typhoid Fever The attack rate for typhoid fever (Chap. 54) is 1 case per 30,000 per month of travel to the developing world. However, the attack rates in India, Senegal, and North Africa are tenfold higher and are especially high among travelers to relatively remote destinations and among VFRs (immigrants returning to their homelands to visit friends or relatives).


Between 1994 and 1999 in the United States, 77% of imported cases involved the latter group. Both of the available vaccines—one oral (live) and the other injectable (polysaccharide)—have efficacy rates of ∼70%. In some countries, a combined hepatitis A/ typhoid vaccine is available. Meningococcal Meningitis Although the risk of meningococcal disease among travelers has not been quantified, it is likely to be higher among travelers who live with poor indigenous populations in overcrowded conditions (Chap. 44). Either the older polysaccharide vaccine or the newer quadrivalent conjugate vaccine is recommended for persons traveling to Sub-Saharan Africa during the dry season or to areas of the world where there are epidemics. The vaccine, which protects against serogroups A, C,Y, and W-135, has an efficacy rate of >90%. Japanese Encephalitis The risk of Japanese encephalitis (Chap. 99), an infection transmitted by mosquitoes in rural Asia and Southeast Asia, is ∼1 case per 5000 travelers per month of stay in an endemic area. Most symptomatic infections among U.S. residents have involved military personnel or their families. The vaccine efficacy rate is >90%; serious allergic reactions occur only rarely.The vaccine is recommended for persons staying >1 month in rural endemic areas or for shorter periods if their activities (e.g., camping, bicycling, hiking) in these areas will increase exposure risk. A Vero cell vaccine may be licensed in the United States within the next 2 years. Cholera The risk of cholera (Chap. 57) is extremely low, with ∼1 case per 500,000 journeys to endemic areas.


Cholera vaccine, no longer available in the United States,was rarely recommended but was considered for aid and health care workers in refugee camps or in disaster-stricken/war-torn areas. A more effective oral cholera vaccine is available in other countries. Rabies Domestic animals, primarily dogs, are the major transmitters of rabies in developing countries (Chap. 98). Several studies have shown that the risk of rabies posed by a dog bite in an endemic area translates into 1–3.6 cases per 1000 travelers per month of stay. Countries where canine rabies is highly endemic include Mexico, the Philippines, Sri Lanka, India, Thailand, and Vietnam. The three vaccines available in the United States provide >90% protection. Rabies vaccine is recommended for long-stay travelers, particularly children, and persons who may be occupationally exposed to rabies in endemic areas. Even after receipt of a preexposure rabies vaccine series, two postexposure doses are required.Travelers who have had the preexposure series will not require rabies immune globulin (which is often unavailable in developing countries) if they are exposed to the disease.


PREVENTION OF MALARIA AND OTHER INSECT-BORNE DISEASES

It is estimated that more than 30,000 American and European travelers develop malaria each year (Chap. 116).The risk to travelers is highest in Oceania and Sub-Saharan Africa (estimated at 1:5 and 1:50 per month of stay, respectively, among persons not using chemoprophylaxis); intermediate in malarious areas on the Indian subcontinent and in Southeast Asia (1:250–1:1000 per month); and low in South and Central America (1:2500–1:10,000 per month). Of the more than 1000 cases of malaria reported annually in the United States, 90% of those due to Plasmodium falciparum occur in travelers returning or immigrating from Africa and Oceania.VFRs are at the highest risk of acquiring malaria.With the worldwide increase in chloroquine- and multidrug-resistant falciparum malaria, decisions about chemoprophylaxis have become more difficult. In addition, the spread of malaria due to primaquine- and chloroquine-resistant strains of Plasmodium vivax has added to the complexity of treatment. The case-fatality rate of falciparum malaria in the United States is 4%; however, in only one-third of patients who die is the diagnosis of malaria considered before death. Several studies indicate that fewer than 50% of travelers adhere to basic recommendations for malaria prevention. Keys to the prevention of malaria include both personal protection measures against mosquito bites (especially between dusk and dawn) and malaria chemoprophylaxis. The former measures include the use of DEET-containing insect repellents, permethrin-impregnated bed-nets and clothing, screened sleeping accommodations, and protective clothing. A new insect repellent containing picaridin as an active ingredient appears to be quite efficacious and is available in the United States only in low-concentration formulations that require frequent reapplications. Thus, in regions where infections such as malaria are transmitted, DEET products (25–50%) are recommended, even for children and infants >2 months of age. Personal protection measures also help prevent other insect-transmitted illnesses, such as dengue fever (Chap. 99). Over the past decade, the incidence of dengue has increased, particularly in the Caribbean region, Latin America, and Southeast Asia. Dengue virus is transmitted by an urban-dwelling mosquito that bites primarily at dawn and dusk. Table 4-2 lists the currently recommended drugs of choice for prophylaxis of malaria, by destination.


PREVENTION OF GASTROINTESTINAL ILLNESS

Diarrhea, the leading cause of illness in travelers (Chap. 25), is usually a short-lived, self-limited condition; however, 40% of affected individuals need to alter their scheduled activities, and another 20% are confined to bed. The most important determinant of risk is the destination. Incidence rates per 2-week stay have been reported to be as low as 8% in industrialized countries and as high as 55% in parts of Africa, Central and South America, and Southeast Asia. Infants and young adults are at particularly high risk. A recent review suggested that there is little correlation between dietary indiscretions and the occurrence of travelers’ diarrhea. Earlier studies of U.S. students in Mexico showed that eating meals in restaurants and cafeterias or consuming food from street vendors was associated with increased risk. Etiology (See also Table 25-3) The most frequently identified pathogens causing travelers’ diarrhea are toxigenic Escherichia coli and enteroaggregative E. coli (Chap. 51), although in some parts of the world (notably northern Africa and Southeast Asia) Campylobacter infections (Chap. 56) appear to predominate. Other common causative organisms include Salmonella (Chap. 54), Shigella (Chap. 55), rotavirus (Chap. 91), and norovirus (Chap. 91). The latter virus has caused numerous outbreaks on cruise ships. Except for giardiasis (Chap. 122), parasitic infections are uncommon causes of travelers’ diarrhea. A growing problem for travelers is the development of antibiotic resistance among many bacterial pathogens. Examples include strains of Campylobacter resistant to quinolones and strains of E. coli, Shigella, and Salmonella resistant to trimethoprim-sulfamethoxazole. Precautions Although the mainstay of prevention of travelers’ diarrhea involves food and water precautions, the literature has repeatedly documented dietary indiscretions by 98% of travelers within the first 72 h after arrival at their destination.


The maxim “Boil it, cook it, peel it, 47 or forget it!” is easy to remember, but apparently difficult to follow. General food and water precautions include eating foods piping hot; avoiding foods that are raw, poorly cooked, or sold by street vendors; and drinking only boiled or commercially bottled beverages, particularly those that are carbonated. Heating kills diarrhea-causing organisms, whereas freezing does not; therefore, ice cubes made from unpurified water should be avoided. Self-Treatment (See also Table 25-5) As travelers’ diarrhea often occurs despite rigorous food and water precautions, travelers should carry medications for self-treatment.An antibiotic is useful in reducing the frequency of bowel movements and duration of illness in moderate to severe diarrhea. The standard regimen is a 3-day course of a quinolone taken twice daily (or, in the case of some newer formulations, once daily). However, studies have shown that a single double dose of a quinolone may be equally effective. For diarrhea acquired in areas such as Thailand, where >90% of Campylobacter infections are quinolone resistant, azithromycin may be a better alternative. Rifaximin, a poorly absorbed rifampin derivative, is highly effective against noninvasive bacterial pathogens such as toxigenic and enteroaggregative E. coli. The current approach to self-treatment of travelers’ diarrhea is for the traveler to carry three once-daily doses of an antibiotic and to use as many doses as necessary to resolve the illness. If neither high fever nor blood in the stool accompanies the diarrhea, loperamide may be taken in combination with the antibiotic. Prophylaxis Prophylaxis of travelers’ diarrhea with bismuth subsalicylate is widely used but is only ∼60% effective. For certain individuals (e.g., athletes, persons with a repeated history of travelers’ diarrhea, and persons with chronic diseases), a single daily dose of a quinolone or azithromycin or a once-daily rifaximin regimen during travel of <1 month’s duration is 75–90% efficacious in preventing travelers’ diarrhea. Illness after Return Although extremely common, acute travelers’ diarrhea is usually self-limited or amenable to antibiotic therapy.


Persistent bowel problems after the traveler returns home have a less well-defined etiology and may require medical attention from a specialist. Infectious agents (e.g., Giardia lamblia, Cyclospora cayetanensis, Entamoeba histolytica) appear to be responsible for only a small proportion of cases with persistent bowel symptoms. By far the most frequent causes of persistent diarrhea after travel are postinfectious sequelae such as lactose intolerance or irritable bowel syndrome. A recent meta-analysis showed that postinfectious irritable bowel syndrome may occur in as many as 4–13% of cases. When no infectious etiology can be identified, a trial of metronidazole therapy for presumed giardiasis, a strict lactose-free diet for 1 week, or a several-week trial of high-dose hydrophilic mucilloid (plus lactulose for persons with constipation) relieves the symptoms of many patients.


PREVENTION OF OTHER TRAVEL-RELATED PROBLEMS

Travelers are at high risk for sexually transmitted diseases (Chap. 28). Surveys have shown that large numbers engage in casual sex, and there is a reluctance to use condoms consistently. An increasing number of travelers are being diagnosed with schistosomiasis (Chap. 126). Travelers should be cautioned to avoid bathing, swimming, or wading in freshwater lakes, streams, or rivers in parts of tropical South America, the Caribbean, Africa, and Southeast Asia. Prevention of travel-associated injury depends mostly on common-sense precautions. Riding on motorcycles (especially without helmets) and in overcrowded public vehicles is not recommended; individuals should not travel in developing countries by road after dark, particularly in rural areas. In addition to its association with motor vehicle accidents, excessive alcohol use has been a significant factor in drownings, assaults, and injuries. Travelers are cautioned to avoid walking barefoot because of the risk of hookworm and Strongyloides infections (Chap. 124) and snakebites.


THE TRAVELER’S MEDICAL KIT

A traveler’s medical kit is strongly advisable.The contents may vary widely, depending on the itinerary, duration of stay, style of travel, and local medical facilities. Although many medications are available abroad (often over the counter), directions for their use may be nonexistent or in a foreign language, or a product may be outdated or counterfeit. For example, a recent multicountry study in Southeast Asia showed that a mean of 53% (range, 21–92%) of antimalarial products were counterfeit or contained inadequate amounts of active drug. In the medical kit, the short-term traveler should consider carrying an analgesic; an antidiarrheal agent and an antibiotic for self-treatment of travelers’ diarrhea; antihistamines; a laxative; oral rehydration salts; a sunscreen with a skinprotection factor of at least 30; a DEET-containing insect repellent for the skin; an insecticide for clothing (permethrin); and, if necessary, an antimalarial drug. To these medications, the long-stay traveler might add a broad-spectrum general-purpose antibiotic (levofloxacin or azithromycin), an antibacterial eye and skin ointment, and a topical antifungal cream. Regardless of the duration of travel, a first-aid kit containing such items as scissors, tweezers, and bandages should be considered. A practical approach to self-treatment of infections in the long-stay traveler who carries a once-daily dose of antibiotics is to use 3 tablets “below the waist” (bowel and bladder infections) and 6 tablets “above the waist” (skin and respiratory infections).


TRAVEL AND SPECIAL HOSTS PREGNANCY AND TRAVEL

A woman’s medical history and itinerary, the quality of medical care at her destinations, and her degree of flexibility determine whether travel is wise during pregnancy. According to the American College of Obstetrics and Gynecology, the safest part of pregnancy in which to travel is between 18 and 24 weeks, when there is the least danger of spontaneous abortion or premature labor. Some obstetricians prefer that women stay within a few hundred miles of home after the 28th week of pregnancy in case problems arise. In general, however, healthy women may be advised that it is acceptable to travel. Relative contraindications to international travel during pregnancy include a history of miscarriage, premature labor, incompetent cervix, or toxemia. General medical problems such as diabetes, heart failure, severe anemia, or a history of thromboembolic disease should also prompt the pregnant woman to postpone her travels. Finally, regions in which the pregnant woman and her fetus may be at excessive risk (e.g., those at high altitudes and those where live-virus vaccines are required or where multidrug-resistant malaria is endemic) are not ideal destinations during any trimester. Malaria Malaria during pregnancy carries a significant risk of morbidity and death. Levels of parasitemia are highest and failure to clear the parasites after treatment is most frequent among primigravidae. Severe disease, with complications such as cerebral malaria, massive hemolysis, and renal failure, is especially likely in pregnancy. Fetal sequelae include spontaneous abortion, stillbirth, preterm delivery, and congenital infection. Travelers’ Diarrhea Pregnant travelers must be extremely cautious regarding their food and beverage intake. Dehydration due to travelers’ diarrhea can lead to inadequate placental blood flow. Infections such as toxoplasmosis, hepatitis E, and listeriosis can also have serious sequelae in pregnancy. The mainstay of therapy for travelers’ diarrhea is rehydration. Loperamide may be used if necessary. For selftreatment, azithromycin may be the best option.Although quinolones are increasingly being used safely during pregnancy and rifaximin is poorly absorbed from the gastrointestinal tract, they are not approved for this indication. Because of the major problems encountered when infants are given local foods and beverages, women are strongly encouraged to breast-feed when traveling with a neonate.


A nursing mother with travelers’ diarrhea should not stop breast-feeding, but should increase her fluid intake. Air Travel and High-Altitude Destinations Commercial air travel is not a risk to the healthy pregnant woman or to the fetus. The higher radiation levels reported at altitudes of >10,500 m (>35,000 ft) should pose no problem to the healthy pregnant traveler. Since each airline has a policy regarding pregnancy and flying, it is best to check with the specific carrier when booking reservations. Domestic air travel is usually permitted until the 36th week, whereas international air travel is generally curtailed after the 32nd week. There are no known risks for pregnant women who travel to high-altitude destinations and stay for short periods. However, there are likewise no data on the safety of pregnant women at altitudes of >4500 m (15,000 ft).


THE HIV-INFECTED TRAVELER (See also Chap. 90)

The HIV-infected traveler is at special risk of serious infections due to a number of pathogens that may be more prevalent at travel destinations than at home. However, the degree of risk depends primarily on the state of the immune system at the time of travel. For persons whose CD4+ T cell counts are normal or >500/ìL, no data suggest a greater risk during travel than for persons without HIV infection. Individuals with AIDS (CD4+ T cell counts of <200/ìL) and others who are symptomatic need special counseling and should visit a travel medicine practitioner before departure, especially when traveling to the developing world. Several countries now routinely deny entry to HIVpositive individuals, even though these restrictions do not appear to decrease rates of transmission of the virus. In general, HIV testing is required of those individuals who wish to stay abroad >3 months or who intend to work or study abroad. Some countries will accept an HIV serologic test done within 6 months of departure, whereas others will not accept a blood test done at any time in the traveler’s home country. Border officials often have the authority to make inquiries of individuals entering a country and to check the medications they are carrying. If a drug such as zidovudine is identified, the person may be barred from entering the country.


Information on testing requirements for specific countries is available from consular offices but is subject to frequent change. Immunizations All of the HIV-infected traveler’s routine immunizations should be up to date (Chap. 3). The response to immunization may be impaired at CD4+ T cell counts of <200/ìL (and in some cases at even higher counts). Thus HIV-infected persons should be vaccinated as early as possible to ensure adequate immune responses to all vaccines. In patients receiving highly active antiretroviral therapy, at least 3 months must elapse before regenerated CD4+ T cells can be considered fully functional; therefore, in these patients, vaccinations should be delayed. However, when the risk of illness is high or the sequelae of illness are serious, immunization is recommended. In certain circumstances, it may be prudent to check the adequacy of the serum antibody response before departure. Because of the increased risk of infections due to Streptococcus pneumoniae and other bacterial pathogens that cause pneumonia after influenza, pneumococcal polysaccharide and influenza vaccines should be administered. The estimated rates of response to influenza vaccine are >80% among persons with asymptomatic HIV infection 49 and <50% among those with AIDS. In general, live attenuated vaccines are contraindicated for persons with immune dysfunction. Because measles (rubeola) can be a severe and lethal infection in HIVpositive patients, these patients should receive the measles vaccine (or the combination measles-mumps-rubella vaccine) unless the CD4+ T cell count is <200/ìL. Between 18% and 58% of symptomatic HIV-infected vaccinees develop adequate antibody titers, and 50–100% of asymptomatic HIV-infected persons seroconvert. It is recommended that the live yellow fever vaccine not be given to HIV-infected travelers. Although the potential adverse effects of a live vaccine in an HIVinfected individual are always a consideration, there appear to have been no reported cases of illness in those who have inadvertently received this vaccine.


Nonetheless, if the CD4+ T cell count is <200/ìL, an alternative itinerary that poses no risk of exposure to yellow fever is recommended. If the traveler is passing through or traveling to an area where the vaccine is required but the disease risk is low, a physician’s waiver should be issued. A transient increase in viremia (lasting days to weeks) has been demonstrated in HIV-infected individuals after immunization against influenza, pneumococcal infection, and tetanus (Chap. 90). However, at this point, there is no evidence that this transient increase is detrimental. Gastrointestinal Illness Decreased levels of gastric acid, abnormal gastrointestinal mucosal immunity, other complications of HIV infection, and medications taken by HIV-infected patients make travelers’ diarrhea especially problematic in these individuals. Travelers’ diarrhea is likely to occur more frequently, be more severe, be accompanied by bacteremia, and be more difficult to treat. Although uncommon, Cryptosporidium, Isospora belli, and Microsporidium infections are associated with increased morbidity and mortality in AIDS patients. The HIV-infected traveler must be careful to consume only appropriately prepared foods and beverages and may benefit from antibiotic prophylaxis for travelers’ diarrhea. Sulfonamides (as used to prevent pneumocystosis) are ineffective because of widespread resistance. Other Travel-Related Infections Data are lacking on the severity of many vector-borne diseases in HIV-infected individuals. Malaria is especially severe in asplenic persons and in those with AIDS.The HIV load doubles during malaria, with subsidence in ∼8–9 weeks; the significance of this increase in viral load is unknown. Visceral leishmaniasis (Chap. 119) has been reported in numerous HIV-infected travelers. Diagnosis may be difficult, given that splenomegaly and hyperglobulinemia are often lacking and serologic results are frequently negative.


Sandfly bites may be prevented by evening use of insect repellents. Certain respiratory illnesses, such as histoplasmosis and coccidioidomycosis, cause greater morbidity and mortality among patients with AIDS. Although tuberculosis is common among HIV-infected persons (especially in developing countries), its acquisition by the short-term HIV-infected traveler has not been reported as a major problem. Medications Adverse events due to medications and drug interactions are common and raise complex issues for HIV-infected persons. Rates of cutaneous reaction (e.g., increased cutaneous sensitivity to sulfonamides) are unusually high among patients with AIDS. Since zidovudine is metabolized by hepatic glucuronidation, inhibitors of this process may elevate serum levels of the drug. Concomitant administration of the antimalarial drug mefloquine and the antiretroviral agent ritonavir may result in decreased plasma levels of ritonavir. In contrast, no significant influence of concomitant mefloquine administration on plasma levels of indinavir or nelfinavir was detected in two HIV-infected travelers.There is a strong theoretical concern that the antimalarial drugs lumefantrine (combined with artemisinin in Coartem and Riamet) and halofantrine may interact with HIV protease inhibitors and nonnucleoside reverse transcriptase inhibitors since the latter are known to be potent inhibitors of cytochrome P450.


CHRONIC ILLNESS, DISABILITY, AND TRAVEL

Chronic health problems need not prevent travel, but special measures can make the journey safer and more comfortable. Heart Disease Cardiovascular events are the main cause of deaths among travelers and of in-flight emergencies on commercial aircraft. Extra supplies of all medications should be kept in carry-on luggage, along with a copy of a recent electrocardiogram and the name and telephone number of the traveler’s physician at home. Pacemakers are not affected by airport security devices, although electronic telephone checks of pacemaker function cannot be transmitted by international satellites. Travelers with electronic defibrillators should carry a note to that effect and ask for hand screening. A traveler may benefit from supplemental oxygen; since oxygen delivery systems are not standard, supplementary oxygen should be ordered by the traveler’s physician well before flight time. Travelers may benefit from aisle seating and should walk, perform stretching and flexing exercises, consider wearing support hose, and remain hydrated during the flight to prevent venous thrombosis and pulmonary embolism. Chronic Lung Disease Chronic obstructive pulmonary disease is one of the most common diagnoses in patients who require emergency-department evaluation for symptoms occurring during airline flights.The best predictor of the development of in-flight problems is the sea-level PaO2.A PaO2 of at least 72 mmHg corresponds to an in-flight arterial PaO2 of ∼55 mmHg when the cabin is pressurized to 2500 m (8000 ft). If the traveler’s baseline PaO2 is <72 mmHg, the provision of supplemental oxygen should be considered.


Contraindications to flight include active bronchospasm, lower respiratory infection, lower-limb deep-vein phlebitis, pulmonary hypertension, and recent thoracic surgery (within the preceding 3 weeks) or pneumothorax. Decreased outdoor activity at the destination should be considered if air pollution is excessive. Diabetes Mellitus Alterations in glucose control and changes in insulin requirements are common problems among patients with diabetes who travel. Changes in time zone, in the amount and timing of food intake, and in physical activity demand vigilant assessment of metabolic control. The traveler with diabetes should pack medication (including a bottle of regular insulin for emergencies), insulin syringes and needles, equipment and supplies for glucose monitoring, and snacks in carry-on luggage. Insulin is stable for ∼3 months at room temperature but should be kept as cool as possible. The name and telephone number of the home physician and a card and bracelet listing the patient’s medical problems and the type and dose of insulin used should accompany the traveler. In traveling eastward (e.g., from the United States to Europe), the morning insulin dose on arrival may need to be decreased. The blood glucose can then be checked during the day to determine whether additional insulin is required. For flights westward, with lengthening of the day, an additional dose of regular insulin may be required.


Other Special Groups Other groups for whom special travel measures are encouraged include patients undergoing dialysis, those with transplants, and those with other disabilities. Up to 13% of travelers have some disability, but few advocacy groups and tour companies dedicate themselves to this growing population. Medication interactions are a source of serious concern for these travelers, and appropriate medical information should be carried, along with the home physician’s name and telephone number. Some travelers taking glucocorticoids carry stress doses in case they become ill. Immunization of these immunocompromised travelers may result in less than adequate protection.Thus the traveler and the physician must carefully consider which destinations are appropriate.


PROBLEMS AFTER RETURN

The most common medical problems encountered by travelers after their return home are diarrhea, fever, respiratory illnesses, and skin diseases (Fig. 4-2). Frequently ignored problems are fatigue and emotional stress, especially in long-stay travelers.The approach to diagnosis requires some knowledge of geographic medicine, in particular, the epidemiology and clinical presentation of infectious disorders.A geographic history should focus on the traveler’s exact itinerary, including dates of arrival and departure; exposure history (food indiscretions, drinkingwater sources, freshwater contact, sexual activity, animal contact, insect bites); location and style of travel (urban vs rural, first-class hotel accommodation vs camping); immunization history; and use of antimalarial chemosuppression.


DIARRHEA See “Prevention of Gastrointestinal Illness” earlier in the chapter. FEVER Fever in a traveler who has returned from a malarious area should be considered a medical emergency because death from P. falciparum malaria can follow an illness of only several days’ duration. Although “fever from the tropics” does not always have a tropical cause, malaria should be the first diagnosis considered. The risk of P. falciparum malaria is highest among travelers returning from Africa or Oceania and among those who become symptomatic within the first 2 months after return. Other important causes of fever after travel include viral hepatitis (hepatitis A and E), typhoid fever, bacterial enteritis, arboviral infections (e.g., dengue fever), rickettsial infections (including tick and scrub typhus and Q fever), and—in rare instances—leptospirosis, acute HIV infection, and amebic liver abscess.A cooperative study by GeoSentinel (an emerging infectious disease surveillance group established by the CDC and the International Society of Travel Medicine) showed that, among 3907 febrile returned travelers, malaria was acquired most often from Africa, dengue from Southeast Asia and the Caribbean, typhoid fever from southern Asia, and rickettsial infections (tick typhus) from southern Africa (Table 4-3). In at least 25% of cases, no etiology can be found, and the illness resolves spontaneously. Clinicians should keep in mind that no present-day antimalarial agent guarantees protection from malaria and that some immunizations (notably, that against typhoid fever) are only partially protective.


When no specific diagnosis is forthcoming, the following investigations, where applicable, are suggested: complete blood count, liver function tests, thick/thin blood films for malaria (repeated twice if necessary), urinalysis, urine and blood cultures (repeated once), chest x-ray, and collection of an acute-phase serum sample to be held for subsequent examination along with a paired convalescent-phase serum sample. SKIN DISEASES Pyodermas, sunburn, insect bites, skin ulcers, and cutaneous larva migrans are the most common skin conditions affecting travelers after their return home. In those with persistent skin ulcers, a diagnosis of cutaneous leishmaniasis, mycobacterial infection, or fungal infection should be considered. Careful, complete inspection of the skin is important in detecting the rickettsial eschar in a febrile patient or the central breathing hole in a “boil” due to myiasis. EMERGING INFECTIOUS DISEASES In recent years, travel and commerce have fostered the worldwide spread of HIV infection, led to the reemergence of cholera as a global health threat, and created considerable fear about the possible spread of severe acute respiratory syndrome (SARS) and avian influenza (H5N1). For travelers, there are more realistic concerns. One of the largest outbreaks of dengue fever ever documented is now raging in Latin America; schistosomiasis is being described in previously unaffected lakes in Africa; and antibiotic-resistant strains of sexually transmitted and enteric pathogens are emerging at an alarming rate in the developing world. In addition, concerns have been raised about the potential for bioterrorism involving not only standard strains of unusual agents but mutant strains as well. Time will tell whether travelers (as well as persons at home) will routinely be vaccinated against diseases such as anthrax and smallpox.As Nobel laureate Dr. Joshua Lederberg pointed out,“The microbe that felled one child in a distant continent yesterday can reach yours today and seed a global pandemic tomorrow.” The vigilant clinician understands that the importance of a thorough travel history cannot be overemphasized.   ​